An exploratory pilot study with plasma protein signatures associated with response of patients with depression to antidepressant treatment for 10 weeks

Title
An exploratory pilot study with plasma protein signatures associated with response of patients with depression to antidepressant treatment for 10 weeks
Authors
민호필김은영안희성이민영유지영염정훈정황교이현정김경곤안영민
Keywords
major depressive disorder; longitudinal study; LC-MS/MS; plasma protein biomarker; drug response monitoring; multiple reaction monitoring
Issue Date
2020-10
Publisher
Biomedicines
Citation
VOL 8, 455
Abstract
: Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent course. Recognition of biological markers that could predict and monitor response todrug treatment could personalize clinical decision-making, minimize unnecessary drug exposure, and achieve better outcomes. Four longitudinal plasma samples were collected from each of tenpatients with MDD treated with antidepressants for 10 weeks. Plasma proteins were analyzed qualitatively and quantitatively with a nanoflow LC?MS/MS technique. Of 1153 proteins identified in the 40 longitudinal plasma samples, 37 proteins were significantly associated with response/time and clustered into six according to time and response by the linear mixed model. Among them, threeearly-drug response markers (PHOX2B, SH3BGRL3, and YWHAE) detectable within one week were verified by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS)in the well-controlled 24 patients. In addition, 11 pr
URI
http://pubs.kist.re.kr/handle/201004/71987
ISSN
2227-9059
Appears in Collections:
KIST Publication > Article
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