An exploratory pilot study with plasma protein signatures associated with response of patients with depression to antidepressant treatment for 10 weeks
- An exploratory pilot study with plasma protein signatures associated with response of patients with depression to antidepressant treatment for 10 weeks
- 민호필; 김은영; 안희성; 이민영; 유지영; 염정훈; 정황교; 이현정; 김경곤; 안영민
- major depressive disorder; longitudinal study; LC-MS/MS; plasma protein biomarker; drug response monitoring; multiple reaction monitoring
- Issue Date
- VOL 8, 455
- : Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent course. Recognition of biological markers that could predict and monitor response todrug treatment could personalize clinical decision-making, minimize unnecessary drug exposure, and achieve better outcomes. Four longitudinal plasma samples were collected from each of tenpatients with MDD treated with antidepressants for 10 weeks. Plasma proteins were analyzed qualitatively and quantitatively with a nanoflow LC？MS/MS technique. Of 1153 proteins identified in the 40 longitudinal plasma samples, 37 proteins were significantly associated with response/time and clustered into six according to time and response by the linear mixed model. Among them, threeearly-drug response markers (PHOX2B, SH3BGRL3, and YWHAE) detectable within one week were verified by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS)in the well-controlled 24 patients. In addition, 11 pr
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