NELL2 Function in Axon Development of Hippocampal Neurons

Title
NELL2 Function in Axon Development of Hippocampal Neurons
Authors
황은미Han Rae KimDong Hee KimJi Young AnDasol KangJeong Woo ParkEun Jin SeoIl Ho JangChang Man HaByung Ju Lee
Issue Date
2020-06
Publisher
Molecules and cells
Citation
VOL 43, NO 6-589
Abstract
Neurons have multiple dendrites and single axon. This neuronal polarity is gradually established during early processes of neuronal differentiation: generation of multiple neurites (stages 1-2); differentiation (stage 3) and maturation (stages 4-5) of an axon and dendrites. In this study, we demonstrated that the neuron-specific n-glycosylated protein NELL2 is important for neuronal polarization and axon growth using cultured rat embryonic hippocampal neurons. Endogenous NELL2 expression was gradually increased in parallel with the progression of developmental stages of hippocampal neurons, and overexpression of NELL2 stimulated neuronal polarization and axon growth. In line with these results, knockdown of NELL2 expression resulted in deterioration of neuronal development, including inhibition of neuronal development progression, decreased axon growth and increased axon branching. Inhibitor against extracellular signal-regulated kinase (ERK) dramatically inhibited NELL2-induced progression of neuronal development and axon growth. These results suggest that NELL2 is an important regulator for the morphological development for neuronal polarization and axon growth.
URI
http://pubs.kist.re.kr/handle/201004/72008
ISSN
1016-8478
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KIST Publication > Article
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