Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway

Title
Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway
Authors
정상훈김진철김현수서정수장윤관안상현Ganesan Raja정영미김태진
Issue Date
2020-10
Publisher
Scientific Reports
Citation
VOL 10, 18119
Abstract
Persimmon leaves are known to have some benefcial efects, including ROS elimination, lipid circulation, and neuronal protection. However, their anti-cancer properties and the underlying mechanisms remain unclear. Herein, we show that treatment with the ethanol extract of persimmon, Diospyros kaki, leaves (EEDK) induces cancer cell death and inhibits cell proliferation. Using fuorescence resonance energy transfer (FRET) technology with genetically-encoded biosensors, we frst found that EEDK stimulates a PDGFR-Rac signaling cascade in live cells. Moreover, we found that downstream of the PDGFR-Rac pathway, JNKs are activated by EEDK. In contrast, JNK-downstream inhibitors, such as CoCl2, T-5224, and pepstatin A, attenuated EEDK-induced cell death. Thus, we illustrate that the PDGFR-Rac-JNK signaling axis is triggered by EEDK, leading to cancer cell death, suggesting the extract of persimmon leaves may be a promising anti-cancer agent.
URI
http://pubs.kist.re.kr/handle/201004/72009
ISSN
2045-2322
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KIST Publication > Article
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