Retinal degeneration reduces consistency of network-mediated responses arising in ganglion cells to electric stimulation

Title
Retinal degeneration reduces consistency of network-mediated responses arising in ganglion cells to electric stimulation
Authors
김재헌임매순윤영준안승기장예지이재익Shelley I. Fried
Keywords
Retinal prosthesis; Electrical stimulation; Electrophysiology; Retinal ganglion cell; Variability
Issue Date
2020-09
Publisher
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Citation
VOL 28, NO 9-1930
Abstract
Retinal prostheses use periodic repetition of electrical stimuli to form artificial vision. To enhance the reliability of evoked visual percepts, repeating stimuli need to evoke consistent spiking activity in individual retinal ganglion cells (RGCs). However, it is not well known whether outer retinal degeneration alters the consistency of RGC responses. Hence, here we systematically investigated the trial-to-trial variability in network-mediated responses as a function of the degenerationlevel. We patch-clamprecorded spikes in ON and OFF types of alpha RGCs from rd10 mice at four different postnatal days (P15, P19, P31, and P60), representing distinct stages of degeneration. To assess the consistency of responses, we analyzed variances in spike count and timing across repeats of the same stimulus delivered multiple times. We found the trial-to-trial variability of network-mediated responses increased considerably as the disease progressed. Compared to responses taken before degeneration onset, those of degenerate retinas showed up to ∼70% higher variability(FanoFactor) in spike counts (p < 0.001) and ∼95% lower correlation level in spike timing (p < 0.001). These results indicate consistency weakens significantly in electrically-evoked network-mediated responses and therefore raise concerns about the ability of microelectronic retinal implants to elicit consistent visual percepts at advanced stages of retinal degeneration.
URI
http://pubs.kist.re.kr/handle/201004/72111
ISSN
1534-4320
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KIST Publication > Article
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