Self-detachable UV-curable polymers for open-access microfluidic platforms

Title
Self-detachable UV-curable polymers for open-access microfluidic platforms
Authors
김진현김홍남방석영Dongha TahkSujin HyungJungeun LimJames YuNoo Li Jeon
Issue Date
2020-11
Publisher
Lab on a chip
Citation
VOL 20, NO 22-4224
Abstract
This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.
URI
http://pubs.kist.re.kr/handle/201004/72157
ISSN
1473-0197
Appears in Collections:
KIST Publication > Article
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