Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Title
Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Authors
최기영김태형현하나허로운남건욱양경직김영민이윤석안재윤박재형노영훈
Issue Date
2020-06
Publisher
Chemical communications
Citation
VOL 56, NO 49-6627
Abstract
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
URI
http://pubs.kist.re.kr/handle/201004/72164
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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