Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
- Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
- 최기영; 김태형; 현하나; 허로운; 남건욱; 양경직; 김영민; 이윤석; 안재윤; 박재형; 노영훈
- Issue Date
- Chemical communications
- VOL 56, NO 49-6627
- A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was
developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
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- KIST Publication > Article
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