Self-Assembling b-Glucan Nanomedicine for the Delivery of siRNA

Title
Self-Assembling b-Glucan Nanomedicine for the Delivery of siRNA
Authors
전호정이경우민대진최용현윤세미장재희황장선조용우최종훈
Keywords
beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery
Issue Date
2020-11
Publisher
Biomedicines
Citation
VOL 8, 497
Abstract
We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300?400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high geneloading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells.
URI
http://pubs.kist.re.kr/handle/201004/72192
ISSN
2227-9059
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE