Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming
- Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming
- 최재영; 김성범; 김치열; 박숙영; 김기태; 전종범; 정현정; 최고봉; 권서문; 전준현; 전종성; 강창현; 강석찬; 이용환
- Issue Date
- Nature Communications
- VOL 11, 5845
- Pathogens utilize multiple types of effectors to modulate plant immunity. Although many apoplastic and cytoplasmic effectors have been reported, nuclear effectors have not been well characterized in fungal pathogens. Here, we characterize two nuclear effectors of the rice blast pathogen Magnaporthe oryzae. Both nuclear effectors are secreted via the biotrophic interfacial complex, translocated into the nuclei of initially penetrated and surrounding cells, and reprogram the expression of immunity-associated genes by binding on effector binding elements in rice. Their expression in transgenic rice causes ambivalent immunity: increased susceptibility to M. oryzae and Xanthomonas oryzae pv. oryzae, hemibiotrophic pathogens, but enhanced resistance to Cochliobolus miyabeanus, a necrotrophic pathogen. Our findings help remedy a significant knowledge deficiency in the mechanism of M. oryzae？rice interactions and underscore how effector-mediated manipulation of plant immunity by one pathogen may also affect the disease severity by other pathogens.
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