Ubiquitin-proteasome system (UPS) as a target for anticancer treatment

Title
Ubiquitin-proteasome system (UPS) as a target for anticancer treatment
Authors
박진영조진홍송은주
Issue Date
2020-12
Publisher
Archives of pharmacal research
Citation
VOL 43-1161
Abstract
The ubiquitin?proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics.
URI
http://pubs.kist.re.kr/handle/201004/72261
ISSN
0253-6269
Appears in Collections:
KIST Publication > ETC
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