Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus

Title
Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus
Authors
이재익박기덕이현범김기훈이승은우준성최지원오주은이정무신정임고우현박용민Hankyul KwakSangwoo KimKiyeong SongElliot H. LeeJin Young BaeGo Eun HaSunpil KimJiesi FengYoo Sung KimDongsu LeeTaehwang SonSoon Woo KwonBo-Eun YoonYulong LiYong Chul Bae이창준Eunji Cheong
Issue Date
2020-11
Publisher
Neuron
Citation
VOL 108-706
Abstract
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
URI
http://pubs.kist.re.kr/handle/201004/72288
ISSN
0896-6273
Appears in Collections:
KIST Publication > Article
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