How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD

Title
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD
Authors
정수영류훈설윤희Soomin KiHannah L RyuJunghee Lee
Issue Date
2020-11
Publisher
Frontiers in Molecular Neuroscience
Citation
VOL 17, 593724
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common form of dementia that affects cognition and memory mostly in aged people. AD pathology is characterized by the accumulation of β-amyloid (Aβ) senile plaques and the neurofibrillary tangles of phosphorylated tau, resulting in cell damage and neurodegeneration. The extracellular deposition of Aβ is regarded as an important pathological marker and a principal-agent of neurodegeneration. However, the exact mechanism of Aβ-mediated pathogenesis is not fully understood yet. Recently, a growing body of evidence provides novel insights on the major role of microglia and its noncell-autonomous cycling of Aβ toxicity. Hence, this article provides a comprehensive overview of microglia as a signifi cant player in uncovering the underlying disease mechanisms of AD.
URI
http://pubs.kist.re.kr/handle/201004/72324
ISSN
1662-5099
Appears in Collections:
KIST Publication > ETC
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