Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334

Title
Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334
Authors
류훈현승재Junsang YooJunyeop KimJeong Hun LeeHyein KimSung Joo JangHyo Hyun SeoSeung Taek OhJongpil KimSang Hyun Moh
Issue Date
2020-02
Publisher
Scientific Reports
Citation
VOL 10 10, 3684
Abstract
Porphyra 334 (P334), a mycosporine-like amino acid (MAA), is a secondary metabolite found in diverse marine and terrestrial organisms and has several benefcial efects on fbroblast proliferation, wound healing, and antioxidant activity. Here, we report that P334 accelerates the cell reprogramming process of mouse tail-tip fbroblasts (TTFs) and human dermal papilla (HDP) cells into induced pluripotent stem cells (iPSCs). We found that P334 signifcantly improved the cell reprogramming efciency by activating the tri-methylation of histone 3 lysine 4 (H3K4me3), which controls mesenchymal to epithelial transition (MET) during the reprogramming process. Thus, we found that P334 directly regulates epigenetic changes, providing an efcient approach for natural compound-based cell reprogramming.
URI
http://pubs.kist.re.kr/handle/201004/72327
ISSN
2045-2322
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KIST Publication > Article
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