Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334
- Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334
- 류훈; 현승재; Junsang Yoo; Junyeop Kim; Jeong Hun Lee; Hyein Kim; Sung Joo Jang; Hyo Hyun Seo; Seung Taek Oh; Jongpil Kim; Sang Hyun Moh
- Issue Date
- Scientific Reports
- VOL 10 10, 3684
- Porphyra 334 (P334), a mycosporine-like amino acid (MAA), is a secondary metabolite found in diverse marine and terrestrial organisms and has several benefcial efects on fbroblast proliferation, wound healing, and antioxidant activity. Here, we report that P334 accelerates the cell reprogramming process of mouse tail-tip fbroblasts (TTFs) and human dermal papilla (HDP) cells into induced pluripotent stem cells (iPSCs). We found that P334 signifcantly improved the cell reprogramming efciency by activating the tri-methylation of histone 3 lysine 4 (H3K4me3), which controls mesenchymal to epithelial transition (MET) during the reprogramming process. Thus, we found that P334 directly regulates epigenetic changes, providing an efcient approach for natural compound-based cell reprogramming.
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