PyrPeg, a Blood Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates

Title
PyrPeg, a Blood Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates
Authors
배애님박기덕박종현류훈최지우현승재Yeon Ha JuYunsook ChoiChangdev G. GadheMun Seok KimSeungyeop BaekYoungSoo KimC. Justin LeeBong Rae Cho
Issue Date
2020-06
Publisher
ACS Chemical Neuroscience
Citation
VOL 11, NO 12-1810
Abstract
Amyloid-β (Aβ) tracers have made a significant contribution to the treatment of Alzheimer’s disease (AD) by allowing a definitive diagnosis in living patients. Unfortunately, they also detect tau and other protein aggregates that compromise test accuracy. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. There is no suitable neuritic Aβ probe for two-photon microscopy. Here we report PyrPeg, a novel two-photon fluorescent probe that can selectively target insoluble Aβ rather than tau and α-synuclein aggregates in the AD model brain and postmortem brain. When injected intravenously, PyrPeg detects the neuritic plaques in the brain and olfactory bulb of the AD model. PyrPeg may serve as a useful blood?brain-barrier-penetrating diagnostic tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the living AD brain.
URI
http://pubs.kist.re.kr/handle/201004/72328
ISSN
1948-7193
Appears in Collections:
KIST Publication > Article
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