Gymnaster Koraiensis Extract Alleviated Metabolic Syndrome Symptoms and Stimulated UCP1Independent Energy Consumption via AMPK Activation in White Adipose Tissue
- Gymnaster Koraiensis Extract Alleviated Metabolic Syndrome Symptoms and Stimulated UCP1Independent Energy Consumption via AMPK Activation in White Adipose Tissue
- 정상훈; 노주원; 손양주; 신지민; 정다슬; 탐 티 레; 원효준; 이창호
- Issue Date
- Molecular nutrition & food research
- VOL 64, NO 22, 2000490
Metabolic syndrome and obesity are rising worldwide concerns that are accompanied by adverse health consequences. Here, it is hypothesized that the ethanol extract from Gymnaster koraiensis (GK), an edible Korean plant known for its anticancer and hepatoprotective properties, could attenuate metabolic syndromerelated symptoms in highfat dietaryinduced obese (DIO) mice.
Methods and Results
Administration of 100 mg kg？1 GK extract to DIO mice effectively reduces body and white adipose tissue (WAT) weight. It also reduces cardiovascular disease risk and improves insulin resistance by lowering the fasting blood glucose levels and mitigating oxidative stress and inflammation. Moreover, supplementation with GK causes elevated energy expenditure in WAT by increasing the mitochondrial oxidative capacity and lipid catabolism through upregulated adenosine monophosphateactivated protein kinase (AMPK) signaling. Orlistat is used as a positive control drug due to its widespread use in previous studies. It is found that GK extract causes weight loss, similar to Orlistat, and it additionally shows unique functions, such as upregulation of energy consumption in WAT.
GK extract treatment prominently reduces obesity and its associated metabolic complications, such as hyperlipidemia, hyperglycemia, and insulin resistance. Hence, It can be used as a promising multitarget functional food that can improve metabolic syndromerelated symptoms.
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