Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis

Title
Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis
Authors
이준석디라제 무라레마무눌 하크
Keywords
virus infection; ROS; miRNA
Issue Date
2020-11
Publisher
International journal of molecular sciences
Citation
VOL 21, NO 23, 8962
Abstract
MicroRNAs (miRNAs) are non­coding RNAs that regulate diverse cellular pathways by controlling gene expression. Increasing evidence has revealed their critical involvement in influenza A virus (IAV) pathogenesis. Host?IAV interactions induce different levels of oxidative stress (OS) by disrupting the balance between reactive oxygen species (ROS) and antioxidant factors. It is thought that miRNA may regulate the expression of ROS; conversely, ROS can induce or suppress miRNA expression during IAV infection. Thus, miRNA and OS are the two key factors of IAV infection and pathogenesis. Accordingly, interactions between OS and miRNA during IAV infection might be a critical area forfurtherresearch. In this review, we discuss the crosstalk between miRNAs and OS during IAV infection. Additionally, we highlight the potential of miRNAs as diagnostic markers and therapeutic targets for IAV infections. This knowledge will help us to study host?virus interactions with novel intervention strategies.
URI
http://pubs.kist.re.kr/handle/201004/72390
ISSN
1661-6596
Appears in Collections:
KIST Publication > ETC
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