Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis
- Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis
- 이준석; 디라제 무라레; 마무눌 하크
- virus infection; ROS; miRNA
- Issue Date
- International journal of molecular sciences
- VOL 21, NO 23, 8962
- MicroRNAs (miRNAs) are noncoding RNAs that regulate diverse cellular pathways by controlling gene expression. Increasing evidence has revealed their critical involvement in influenza A virus (IAV) pathogenesis. Host？IAV interactions induce different levels of oxidative stress (OS) by disrupting the balance between reactive oxygen species (ROS) and antioxidant factors. It is thought that miRNA may regulate the expression of ROS; conversely, ROS can induce or suppress miRNA expression during IAV infection. Thus, miRNA and OS are the two key factors of IAV infection and pathogenesis. Accordingly, interactions between OS and miRNA during IAV infection might be a critical area forfurtherresearch. In this review, we discuss the crosstalk between miRNAs and OS during IAV infection. Additionally, we highlight the potential of miRNAs as diagnostic markers and therapeutic targets for IAV infections. This knowledge will help us to study host？virus interactions with novel intervention strategies.
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- KIST Publication > ETC
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