Dynamic changes in balance of basal ganglia circuitry control stress-coping behaviors in mice

Title
Dynamic changes in balance of basal ganglia circuitry control stress-coping behaviors in mice
Authors
고혜영Young LeeNa-Eun HanWonju KimJae Gon KimIn Bum LeeSu Jeong ChoiHeejung ChunMisun SeoC. Justin LeeJoung-Hun KimJa-Hyun BaikMark F. BearSe-Young ChoiBong-June Yoon
Issue Date
2020-04
Publisher
Molecules and cells
Citation
VOL 43, NO 4-372
Abstract
The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) (‘bridging collaterals’) was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.
URI
http://pubs.kist.re.kr/handle/201004/72407
ISSN
1016-8478
Appears in Collections:
KIST Publication > Article
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