Dynamic changes in balance of basal ganglia circuitry control stress-coping behaviors in mice
- Dynamic changes in balance of basal ganglia circuitry control stress-coping behaviors in mice
- 고혜영; Young Lee; Na-Eun Han; Wonju Kim; Jae Gon Kim; In Bum Lee; Su Jeong Choi; Heejung Chun; Misun Seo; C. Justin Lee; Joung-Hun Kim; Ja-Hyun Baik; Mark F. Bear; Se-Young Choi; Bong-June Yoon
- Issue Date
- Molecules and cells
- VOL 43, NO 4-372
- The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) (‘bridging collaterals’) was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.