Differential effects of saikosaponins A, B2, B4, C and D on alcohol and chocolate self-administration in rats

Title
Differential effects of saikosaponins A, B2, B4, C and D on alcohol and chocolate self-administration in rats
Authors
권학철이정환Paola MaccioniIrene LorraiFederica FaraMauro A.M. CaraiGian Luigi Gessa진영원Federico CorelliGiancarlo Colombo
Keywords
사이코사포닌닌; 시호호; 알코올 탐닉닉; 초코렛 탐닉닉; 한-이태리 공동연구구
Issue Date
2020-05
Publisher
Alcohol and alcoholism : international journal of the Medical Council on Alcoholism
Citation
VOL 55, NO 4-373
Abstract
Treatment with saikosaponin A ingredient of the medicinal herb, Bupleurum falcatum-has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alc. and chocolate self-administration in male rats. Saikosaponins of B. falcatum other than SSA affect alc. and chocolate self-administration in rats. Ovariectomized female Sardinian alc.-preferring (sP) and Wistar rats were trained to self-administer alc. and chocolate solution Nesquik in water under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D, saikosaponin C, saikosaponin B2 and saikosaponin B4. All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg. Treatment with SSA and SSD resulted in highly similar, marked reductions in alc. self-administration; SSC failed to alter lever-responding for alc., while SSB2 and SSB4 produced intermediate reductions Wide spectrum of efficacy of saikosaponins in reducing alc. and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacol. profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential.
URI
http://pubs.kist.re.kr/handle/201004/72411
ISSN
0735-0414
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KIST Publication > Article
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