Artifact-Free 2D Mapping of Neural Activity In Vivo through Transparent Gold Nanonetwork Array

Title
Artifact-Free 2D Mapping of Neural Activity In Vivo through Transparent Gold Nanonetwork Array
Authors
최낙원정소현서지원김기업김미경김효정김정욱이정호이정용이현주Ki-Won Seo
Issue Date
2020-08
Publisher
Advanced functional materials
Citation
VOL 30, NO 34, 2000896
Abstract
With the rapid increase in the use of optogenetics to investigate the nervous system, there is a high demand for a neural interface that enables 2D mapping of electrophysiological neural signals with high precision during simultaneous light stimulation. Here, a gold nanonetwork (Au NN)­based transparent neural electrocorticogram (ECoG) monitoring system is proposed as implantable neural electronics. The neural interface enables accurate 2D mapping of ECoG neural signals without any photoelectric artifact during light stimulation. By using the Au NN, not only the transmittance of the microelectrodes is increased by 81% but also a low electrochemical impedance of 33.9 kΩ at 1 kHz with improved mechanical stability is achieved. It is demonstrated that the transparent microelectrode array records multichannel in vivo neural activities with no photoelectric artifact and a high signal­to­noise ratio. Propagation of neural dynamics of optically driven neural activities is also clearly visualized using the 2D Au NN microelectrode array. This transparent, flexible ECoG microelectrode array is a promising candidate for next­generation in vitro and in vivo neural interface for 2D mapping of neural dynamics.
URI
http://pubs.kist.re.kr/handle/201004/72519
ISSN
1616-301X
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