Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway

Title
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway
Authors
임혜원박미경김수연서지연조은실황홍익허영나손희성홍정화최유리이새봄송성은이아람조동규
Issue Date
2021-03
Publisher
Progress in neurobiology
Citation
VOL 198-101915-17
Abstract
While positive regulators of hippocampal long-term potentiation (LTP) have extensively been investigated, relatively little is known about the inhibitory regulators of LTP. We previously reported that Cyclin Y (CCNY), a member of cyclin family generally known to function in proliferating cells, is a novel postsynaptic protein that serves as a negative regulator of functional LTP. However, whether CCNY plays a role in structural LTP, which is mechanistically linked to functional LTP, and which mechanisms are involved in the CCNY-mediated suppression of LTP at the molecular level remain elusive. Here, we report that CCNY negatively regulates the plasticity-induced changes in spine morphology through the control of actin dynamics. We observed that CCNY directly binds to filamentous actin and interferes with LTP-induced actin polymerization as well as depolymerization by blocking the activation of cofilin, an actin-depolymerizing factor, thus resulting in less plastic spines and the impairment of structural LTP. These data suggest that CCNY acts as an inhibitory regulator for both structural and functional LTP by modulating actin dynamics through the cofilin-actin pathway. Collectively, our findings provide a mechanistic insight into the inhibitory modulation of hippocampal LTP by CCNY, highlighting a novel function of a cyclin family protein in non-proliferating neuronal cells.
URI
http://pubs.kist.re.kr/handle/201004/72537
ISSN
0301-0082
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