Nitric oxide releasing lipid bilayer tethered on titanium and its effects on vascular cells

Title
Nitric oxide releasing lipid bilayer tethered on titanium and its effects on vascular cells
Authors
정윤기마무드 엘나갈한동근
Issue Date
2019-12
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 80-819
Abstract
The aim of this study was to investigate the feasibility and potential use of tethered lipid bilayer (tLB) membranes with a lipophilic nitric oxide (NO) donor (10-nitrooleate) incorporated into the bilayer to achieve the controlled release of NO from tLB membrane-anchored on a metal surface. NO releasing tLB membranes were prepared via two steps: (1) tethering phospholipids on a metal surface and (2) fusing NO donor containing liposomes with the lipids pre-tethered on the surface. Surface analyses using Fourier transform infrared (FTIR), fluorescent and confocal and atomic force microscopy (AFM) were utilized to prove the successful tLB formation on titanium surface. Bovine serum albumin and fibrinogen tests showed minimum adsorption on the tLB samples when compared with bare titanium plates. After the incorporation of 10-nitrooleate into the bilayer, the samples exhibited sustained NO release profiles up to 24 h. In vitro cell study demonstrated that NO releasing tLB has pleiotropic effects on endothelial cells and smooth muscle cells. Finally, these results open up a door for the potential use of bioactive gas releasing tLB for biomedical devices.
URI
http://pubs.kist.re.kr/handle/201004/72571
ISSN
1226-086X
Appears in Collections:
KIST Publication > Article
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