Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy
- Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy
- 김인산; 남기훈; 김성아; 최윤정; 김기범; 김서현
- Issue Date
- Advanced materials
- VOL 32, NO 51, 2002440
- Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are secreted by most cells and contain various bioactive molecules reflecting their cellular origin and mediate intercellular communication. Studies of these exosomal features in tumor pathogenesis have led to the development of therapeutic and diagnostic approaches using exosomes for cancer therapy. Exosomes have many advantages for conveying therapeutic agents such as small interfering RNAs, microRNAs, membraneassociated proteins, and chemotherapeutic compounds; thus, they are considered a prime candidate as a delivery tool for cancer treatment. Since exosomes also provide an optimal microenvironment for the effective function of immunomodulatory factors, exosomes harboring bioactive molecules have been bioengineered as cancer immunotherapies that can effectively activate each stage of the cancer immunity cycle to successfully elicit cancerspecific immunity. This review discusses the advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development.
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