Functionalized exosome harboring bioactive molecules for cancer therapy

Title
Functionalized exosome harboring bioactive molecules for cancer therapy
Authors
김인산남기훈최윤정김윤경
Issue Date
2020-10
Publisher
Cancer letters
Citation
VOL 489-162
Abstract
Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. This review can be used as a guideline for further study in expanding the utility of therapeutic exosomes.
URI
http://pubs.kist.re.kr/handle/201004/72583
ISSN
0304-3835
Appears in Collections:
KIST Publication > ETC
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