Maternal Malnutrition Aects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation

Title
Maternal Malnutrition Aects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation
Authors
이정애두지은유영아권은진김수민김기환김영주
Keywords
fetal programming; food restriction; high fat diet; taurine; HNF4A methylation
Issue Date
2020-12
Publisher
International journal of molecular sciences
Citation
VOL 21, NO 23, 9060
Abstract
Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet-related alterations in metabolites and the biological pathway in male offspring at three months of age. Pregnant rats were exposed to 50% food restriction during the prenatal period or a 45% high-fat diet during the prenatal and postnatal periods. The male offspring exposed to food restriction and high-fat diets had lower birth weights than controls, but had a catch-up growth spurt at three months of age. Hepatic taurine levels decreased in both groups compared to controls. The decreased hepatic taurine levels in offspring affected excessive lipid accumulation through changes in hepatocyte nuclear factor 4 A methylation. Moreover, the alteration of gluconeogenesis in offspring exposed to food restriction was observed to a similar extent as that of offspring exposed to a high fat diet. These results indicate that maternal diet affects the dysregulation in hepatic metabolism through changes in taurine levels and HNF4A methylation, and predisposes the offspring to Type 2 diabetes and non-alcoholic fatty liver disease in later life.
URI
http://pubs.kist.re.kr/handle/201004/72601
ISSN
1661-6596
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KIST Publication > Article
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