Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion

Title
Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion
Authors
김호준Jahyun KooSung Bong KimYeon Sik ChoiZhaoqian XieAmay J. BandodkarJawad KhalifehYing YanMaryam Kherad PezhouhKaren DotyGeumbee LeeYu-Yu- ChenSeung Min LeeDominic D'AndreaKimin JungKunHyuck LeeKan LiSeongbin JoHeling WangJae-Hwan KimJeonghyun KimSung-Geun ChoiWoo Jin JangYong Suk OhInkyu ParkSung Soo KwakJi-Hyeon ParkDoosun HongXue FengChi-Hwan LeeAnthony BanksCecilia LealHyuck Mo LeeYonggang HuangColin K FranzWilson Z RayMatthew MacEwanSeung-Kyun KangJohn A Rogers
Issue Date
2020-08
Publisher
Science Advances
Citation
VOL 6, NO 35, eabb1093
Abstract
Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.
URI
http://pubs.kist.re.kr/handle/201004/72682
ISSN
2375-2548
Appears in Collections:
KIST Publication > Article
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