Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models
- Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models
- 최낙원; 이승환; 성종환
- Issue Date
- EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
- VOL 15, NO 12-1019
- Introduction:Afteradministration,adrugundergoesabsorption,distribution,metabolism,andelimination (ADME)beforeexertingitseffectonthebody.Thecombinationoftheseprocessyieldsthepharmacokinetic (PK) and pharmacodynamic (PD) profiles of a drug. Although accurate prediction of PK and PD profiles is essential for drug development, conventional in vitro models are limited by their lack of physiological relevance. Recently, microtechnology-based in vitro model systems, termed ‘organ-on-a-chip,’ have emerged as a potential solution.
Areas covered: Orally administered drugs are absorbed through the intestinal wall and transported to the liver before entering systemic circulation, which plays an important role in the PK and PD profiles. Recently developed, chip-based in vitro models can be useful models for simulating such processes and will be covered in this paper.
Expert opinion: The potential of intestine-on-a-chip models combined with conventional PK-PD modeling has been demonstrated with promising preliminary results. However, there are several challenges to overcome. Development of the intestinal wall, integration of the gut microbiome, and the provision of an intestine-specific environment must be achieved to realize in vivo-like intestinal model and enhance the efficiency of drug development.
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