Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention

Title
Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention
Authors
배애님임지웅이지연
Keywords
TSPO; Alzheimer's Disease; Mitochondrial function
Issue Date
2020-01
Publisher
BMB REPORTS
Citation
VOL 53, NO 1-55
Abstract
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease and has become a major socioeconomic issue in many developed countries. Currently available therapeutic agents for AD provide only symptomatic treatments, mainly because the complete mechanism of the AD pathogenesis is still unclear. Although several different hypotheses have been proposed, mitochondrial dysfunction has gathered interest because of its profound effect on brain bioenergetics and neuronal survival in the pathophysiology of AD. Various therapeutic agents targeting the mitochondrial pathways associated with AD have been developed over the past decade. Although most of these agents are still early in the clinical development process, they are used to restore mitochondrial function, which provides an alternative therapeutic strategy that is likely to slow the progression of the disease. In this mini review, we will survey the AD-related mitochondrial pathways and their small-molecule modulators that have therapeutic potential. We will focus on recently reported examples, and also overview the current challenges and future perspectives of ongoing research.
URI
http://pubs.kist.re.kr/handle/201004/72697
ISSN
1976-6696
Appears in Collections:
KIST Publication > Article
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