Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission

Title
Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission
Authors
손장엽Matteo MoschettaJong-Young LeeJoao RodriguesAlice PodestaOmar VarvicchioYangjin LeeKwanpyo KimGwan-Hyoung LeeFabio BenfenatiMattia BraminiAndrea Capasso
Keywords
2D materials; hydrogenation; hydrophilicity; neurons; poly(ethylene
Issue Date
2021-01
Publisher
Advanced Biology
Citation
VOL 5, NO 1-2000177
Abstract
Graphene is regarded as a viable bio-interface for neuroscience due to its biocompatibility and electrical conductivity, which would contribute to efficient neuronal network signaling. Here, monolayer graphene grown via chemical vapor deposition is treated with remote hydrogen plasma to demonstrate that hydrogenated graphene (HGr) fosters improved cell-to-cell communication with respect to pristine graphene in primary cortical neurons. When transferred to polyethylene terephthalate, HGr exhibits higher wettability than graphene (water contact angle of 83.7° vs 40.7°), while preserving electrical conductivity (?3 kΩ □-1 ). A rich and mature network is observed to develop onto HGr. The intrinsic excitability and firing properties of neurons plated onto HGr appears unaltered, while the basic passive and active membrane properties are fully preserved. The formation of excitatory synaptic connections increases in HGr with respect to pristine graphene, leading to a doubled miniature excitatory postsynaptic current frequency. This study supports the use of hydrogenation for tailoring graphene into an improved neuronal interface, indicating that wettability, more than electrical conductivity, is the key parameter to be controlled. The use of HGr can bring about a deeper understanding of neuronal behavior on artificial bio-interfaces and provide new insight for graphene-based biomedical applications.
URI
http://pubs.kist.re.kr/handle/201004/72699
ISSN
2701-0198
Appears in Collections:
KIST Publication > Article
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