A bird’s-eye view of brain activity in socially interacting mice through mobile edge computing

Title
A bird’s-eye view of brain activity in socially interacting mice through mobile edge computing
Authors
최지현김지수김채우한효빈조철준염우섭이성규
Issue Date
2020-12
Publisher
Science Advances
Citation
VOL 6, NO 49, eabb9841
Abstract
Social cognition requires neural processing, yet a unifying method linking particular brain activities and social behaviors is lacking. Here, we embedded mobile edge computing (MEC) and light emitting diodes (LEDs) on a neurotelemetry headstage, such that a particular neural event of interest is processed by the MEC and subsequently an LED is illuminated, allowing simultaneous temporospatial visualization of that neural event in multiple, socially interacting mice. As a proof of concept, we configured our system to illuminate an LED in response to gamma oscillations in the basolateral amygdala (BLA gamma) in freely moving mice. We identified (i) BLA gamma responses to a spider robot, (ii) affect-related BLA gamma during conflict, and (iii) formation of defensive aggregation under a threat by the robot, and reduction of BLA gamma responses in the inner-located mice. Our system can provide an intuitive framework for examining brain-behavior connections in various ecological situations and population structures.
URI
http://pubs.kist.re.kr/handle/201004/72701
ISSN
2375-2548
Appears in Collections:
KIST Publication > Article
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