Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells

Title
Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells
Authors
이충구강혜지김기천박선희Garima SharmaRavi Verma임신혁권호근
Keywords
probiotics; metabolite; propionate; skin allergy; atopic dermatitis; contact hypersensitivity; Foxp3; Regulatory T cells
Issue Date
2021-04
Publisher
The Journal of allergy and clinical immunology : official organ of American Academy of Allergy
Citation
VOL 147, NO 4-1521
Abstract
Probiotics have shown their potent immunomodulatory effects and are considered a promising alternative for the prevention and treatment of inflammatory disorders. However, lack of precise action mechanisms of probiotics restrained their application, especially for the treatment of non-gastrointestinal diseases such as skin allergies including atopic dermatitis and allergic contact dermatitis. Previously, we have shown that the combination of rationally selected 5 probiotic bacteria strains (known as IRT5) has persuasive therapeutic effects on autoimmunity. However, it is still unclear how oral supplementation of IRT5 modulates the immune system and eventually has therapeutic efficacy in skin allergies such as contact dermatitis and atopic dermatitis. Here, we have investigated the action mechanisms of IRT5 for the induction of FOXP3+ regulatory T (Treg) cells and the resolution of skin inflammations in hapten-induced contact hypersensitivity (CHS) as well as house dust mite?induced atopic dermatitis (AD) as type 1 and type 2 inflammatory skin allergic models, respectively.
URI
http://pubs.kist.re.kr/handle/201004/72745
ISSN
0091-6749
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE