Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells
- Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells
- 이충구; 강혜지; 김기천; 박선희; Garima Sharma; Ravi Verma; 임신혁; 권호근
- probiotics; metabolite; propionate; skin allergy; atopic dermatitis; contact hypersensitivity; Foxp3; Regulatory T cells
- Issue Date
- The Journal of allergy and clinical immunology : official organ of American Academy of Allergy
- VOL 147, NO 4-1521
- Probiotics have shown their potent immunomodulatory effects and are considered a promising alternative for the prevention and treatment of inflammatory disorders. However, lack of precise action mechanisms of probiotics restrained their application, especially for the treatment of non-gastrointestinal diseases such as skin allergies including atopic dermatitis and allergic contact dermatitis. Previously, we have shown that the combination of rationally selected 5 probiotic bacteria strains (known as IRT5) has persuasive therapeutic effects on autoimmunity. However, it is still unclear how oral supplementation of IRT5 modulates the immune system and eventually has therapeutic efficacy in skin allergies such as contact dermatitis and atopic dermatitis. Here, we have investigated the action mechanisms of IRT5 for the induction of FOXP3+ regulatory T (Treg) cells and the resolution of skin inflammations in hapten-induced contact hypersensitivity (CHS) as well as house dust mite？induced atopic dermatitis (AD) as type 1 and type 2 inflammatory skin allergic models, respectively.
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