Development and Therapeutic Potential of NUAKs Inhibitors

Title
Development and Therapeutic Potential of NUAKs Inhibitors
Authors
유경호이소하노은주무하마드 파이잘김재호홍순선
Keywords
NUAK1; NUAK2; ARK5; SNARK; Cancer; Inhibitors
Issue Date
2021-01
Publisher
Journal of medicinal chemistry
Citation
VOL 64, NO 1-25
Abstract
NUAK isoforms, NUAK1 (ARK5) and NUAK2 (SNARK), are important members of the AMPK family of protein kinases. They are involved in a broad spectrum of physiological and cellular events, and sometimes their biological roles overlap. NUAK isoform dysregulation is associated with numerous pathological disorders, including neurodegeneration, metastatic cancer, and diabetes. Therefore, they are promising therapeutic targets in metabolic diseases and cancers; consequently, various NUAK-targeted inhibitors have been disclosed. The first part of this review comprises a brief discussion of the homology, expression, structure, and characteristics of NUAK isoforms. The second part focuses on NUAK isoforms’ involvement in crucial biological operations, including mechanistic findings, highlighting how their abnormal functioning contributes to disease progression and quality of life. The third part summarizes the key findings and applications of targeting NUAK isoforms for treating multiple cancers and neurodegenerative disorders. The final part systematically presents a critical review and analysis of the literature on NUAK isoform inhibitions through small molecules.
URI
http://pubs.kist.re.kr/handle/201004/72750
ISSN
0022-2623
Appears in Collections:
KIST Publication > Article
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