Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes

Title
Polyacrylonitrile-based carbon nanofibers as a matrix for laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules under both positive and negative ionization modes
Authors
이성호양철민채아리이관원고동연김영관
Keywords
Laser desorption/ionization; Mass spectrometry; Carbon nanofiber; Carbonization; Saccharide
Issue Date
2021-01
Publisher
Analytical and bioanalytical chemistry
Citation
VOL 413-1202
Abstract
Carbon fiber (CNF), prepared by carbonization of electrospun polyacrylonitrile (PAN) fibers, is systematically investigated as a mediator to replace conventional organic matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). CNF exhibits a high salt tolerance, sensitivity, and resolution for organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes under both positive and negative ionization modes. Especially, saccharides, a neutral molecule having low negative ionization efficiency, are successfully detected with CNF. Taken together, this study clearly demonstrates CNF is a promising material to develop an efficient and universal platform for LDI-MS analysis regardless of preferential ionization modes of analytes.
URI
http://pubs.kist.re.kr/handle/201004/72755
ISSN
1618-2642
Appears in Collections:
KIST Publication > Article
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