Anti-adipogenic polyacetylene glycosides from the florets of safflower (carthamus tinctorius)

Title
Anti-adipogenic polyacetylene glycosides from the florets of safflower (carthamus tinctorius)
Authors
김진철백수철이상아이범수유재식방창현장태수이재철김기현
Issue Date
2021-01
Publisher
Biomedicines
Citation
VOL 9, NO 91, 91
Abstract
Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family; it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C10-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-β-D-glucopyranoside (1) and (8S)-deca-4,6-diyne1,8-diol-1-O-β-D-glucopyranoside (2), together with five known analogs (3?7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemical transformations. Of compounds 1?7, compounds 2, 3, and 4 inhibited the adipogenesis of 3T3-L1 preadipocytes, whereas compounds 1 and 6 promoted adipogenesis. Compounds 2, 3, and 4 also prevented lipid accumulation through the suppression of the expression of lipogenic genes and the increase of the expression of lipolytic genes. Moreover, compounds 3 and 4 activated AMPK, which is known to facilitate lipid metabolism. Our findings provide a mechanistic rationale for the use of safflower-derived polyacetylene glycosides as potential therapeutic agents against obesity
URI
http://pubs.kist.re.kr/handle/201004/72769
ISSN
2227-9059
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KIST Publication > Article
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