Synthesis of donor/acceptor-substituted diazo compounds in flow and their application in enantioselective dirhodium-catalyzed cyclopropanation and C?H functionalization

Title
Synthesis of donor/acceptor-substituted diazo compounds in flow and their application in enantioselective dirhodium-catalyzed cyclopropanation and C?H functionalization
Authors
유천재Daniel RacklChristopher W. JonesHuw M. L. Davies
Issue Date
2017-06
Publisher
Organic letters
Citation
VOL 19, NO 12-3058
Abstract
A tandem reaction system has been developed for the preparation of donor/acceptor-substituted diazo compounds in continuous flow coupled to dirhodiumcatalyzed C?H functionalization or cyclopropanation. Hydrazones were oxidized in flow by solid-supported N-iodo-ptoluenesulfonamide potassium salt (PS-SO2NIK) to generate the diazo compounds, which were then purified by passing through a column of molecular sieves/sodium thiosulfate.
URI
http://pubs.kist.re.kr/handle/201004/72784
ISSN
1523-7060
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KIST Publication > Article
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