An Immobilized­Dirhodium Hollow­Fiber Flow Reactor for Scalable and Sustainable C? H Functionalization in Continuous Flow

Title
An Immobilized­Dirhodium Hollow­Fiber Flow Reactor for Scalable and Sustainable C? H Functionalization in Continuous Flow
Authors
유천재Daniel RacklWenbin LiuCaroline B. HoytBrian PimentelRyan P. LivelyHuw M. L. DaviesChristopher W. Jones
Issue Date
2018-08
Publisher
Angewandte Chemie international edition
Citation
VOL 57, NO 34-10927
Abstract
A scalable flow reactor is demonstrated for enantioselective and regioselective rhodium carbene reactions (cyclopropanation and C@H functionalization) by developing cascade reaction methods employing a microfluidic flow reactor system containing immobilized dirhodium catalysts in conjunction with the flow synthesis of diazo compounds. This allows the utilization of the energetic diazo compounds in a safe manner and the recycling of the dirhodium catalysts multiple times. This approach is amenable to application in a bulk-scale synthesis employing asymmetric C@H functionalization by stacking multiple fibers in one reactor module. The products from this sequential flow?flow reactor are compared with a conventional batch reactor or flow?batch reactor in terms of yield, regioselectivity, and enantioselectivity.
URI
http://pubs.kist.re.kr/handle/201004/72786
ISSN
1433-7851
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KIST Publication > Article
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