Neuroprotective and anti-inflammatory activity of marine sponge extract and HPLC profiling of its components

Title
Neuroprotective and anti-inflammatory activity of marine sponge extract and HPLC profiling of its components
Authors
박진수이재욱김민선김다은안혜숙
Keywords
Anti-inflammatory activity; High-performance liquid chromatography profiling; Neuroprotective activity; Sponge
Issue Date
2021-02
Publisher
Journal of Applied Biological Chemistry
Citation
VOL 64, NO 1-38
Abstract
Marine sponges contain pharmacologically attractive substances that exhibit strong cytotoxicity and are used as materials to isolate potential drug candidates. However, with a growing interest in marine ecosystem conservation, it is becoming increasingly difficult to gather a sponge for natural product research. To build a database to cope with this issue, we measured the neuroprotective and anti-inflammatory activity of 181 sponge extracts. As a result, we found 17 samples with neuroprotective effects and 14 samples with anti-inflammatory effects. In addition, high-performance liquid chromatography (HPLC) analysis was performed to compare the components contained in each sample, and based on HPLC profiles, a dendrogram according to similarity was created. The results of this study suggested the possibility of discovering the active compounds in the sponge and laid the basis for efficient research on the sponge.
URI
http://pubs.kist.re.kr/handle/201004/72889
ISSN
1976-0442
Appears in Collections:
KIST Publication > Article
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