Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children

Title
Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children
Authors
표희수이정애온지원김신혜박미정이상원
Keywords
Di(2-ethylhexyl)phthalatemetabolite; Relative metabolite ratio; Childhood obesity; Urine; GC-MS/MS
Issue Date
2021-02
Publisher
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Citation
VOL 온라인게재, 온라인게재
Abstract
Phthalate exposure has been reported to be more associated with obesity in children than in adults. The concentration of di(2- ethylhexyl)phthalate (DEHP) was high temporal variability in spot urine, so additional tools of assessing DEHP exposure were required. Therefore, we used relative metabolite ratios (RMRs) as well as concentrations, and RMRs did not need to be corrected to the creatinine concentration.We aimed to evaluate the levels of urinary DEHP metabolites and their RMRs in obese children in South Korea, and to investigate the potential of RMRs for assessing the risks for childhood obesity. We analyzed the four urinary DEHP metabolites (mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl- 5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP)) in 240 children aged 5?16 years, using isotope dilution GC-MS/MS. The children were placed into three groups (“normal weight,” “overweight,” and “obese”) according to body mass index (BMI) percentiles.We statistically compared the concentrations and RMRs of DEHP metabolites among these groups. The obese group had lower MEHP levels, and higher secondary metabolite (MEHHP, MEOHP, and MECPP) levels, than the normal weight group. DEHP metabolite levels did not differ significantly between the normal weight and obese groups, whereas RMRA2 (as the ratio of the molar concentrations ofMEOHP to MEHHP) was found to be negatively associated with BMI percentile (β= ?0.236, p <0.01) and weight percentile (β= ?0.282, p<0.001). Therefore, we suggest that RMRs are an additional tool for assessing the health risks of DEHP.
URI
http://pubs.kist.re.kr/handle/201004/72890
ISSN
0944-1344
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KIST Publication > Article
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