Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

Title
Origami paper-based sample preconcentration using sequentially driven ion concentration polarization
Authors
강지윤곽승민이준우유용경이도환김전중김강현이승민김혁성윤대성허돈이정훈
Issue Date
2021-01
Publisher
Lab on a chip
Citation
VOL 21, NO 5-874
Abstract
Ion concentration polarization (ICP) is one of the preconcentration techniques which can acquire a high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency under physiological conditions with high ionic strength and abundant biomolecules. Here, we suggested a sequentially driven ICP process, which enhanced the electrokinetic force required for preconcentration, enabling enrichment of highly ionic raw samples without increasing the electric field. We acquired a 13-fold preconcentration factor (PF) in human serum using a paper-based origami structure consisting of multiple layers for three-dimensional sequential ICP (3D seq-ICP). Moreover, we demonstrated a paper-based enzyme-linked immunosorbent assay (ELISA) by 3D seq-ICP using tau protein, showing a 6-fold increase in ELISA signals.
URI
http://pubs.kist.re.kr/handle/201004/72924
ISSN
1473-0197
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KIST Publication > Article
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