Alterations in Pattern Baldness According to Sex: hair metabolomics approach

Title
Alterations in Pattern Baldness According to Sex: hair metabolomics approach
Authors
정봉철이유라유박린심우영홍종기
Keywords
hair metabolomics; HLPC/MS; pattern baldness; female; male
Issue Date
2021-03
Publisher
Metabolites
Citation
VOL 11-178-13
Abstract
Pattern baldness has been associated with the male hormone, dihydrotestosterone. In this study, we tried to determine how the overall metabolic pathways of pattern baldness differ in patients and in normal controls. Our study aimed to identify alterations in hair metabolomic profiles in order to identify possible markers of pattern baldness according to sex. Untargeted metabolomics profiling in pattern baldness patients and control subjects was conducted using ultra-performance liquid chromatography-mass spectrometry. To identify significantly altered metabolic pathways, partial least squares discriminant analysis was performed. Our analysis indicated differences in steroid biosynthesis pathway in both males and females. However, there was a remarkable difference in the androgen metabolic pathway in males, and the estrogen metabolic and arachidonic acid pathways in females. For the first time, we were able to confirm the metabolic pathway in pattern baldness patients using hair samples. Our finding improves understanding of pattern baldness and highlights the need to link pattern baldness and sex-related differences.
URI
http://pubs.kist.re.kr/handle/201004/72973
ISSN
2218-1989
Appears in Collections:
KIST Publication > Article
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