Mass Spectrometry-Based Steroid Profiling: Meeting Unmet Clinical Needs

Title
Mass Spectrometry-Based Steroid Profiling: Meeting Unmet Clinical Needs
Authors
최만호
Keywords
adrenal gland; cholesterol; clinical application; mass spectrometry; steroids
Issue Date
2021-03
Publisher
The Tohoku journal of experimental medicine
Citation
VOL 253, NO 3-180
Abstract
Despite ongoing concerns regarding its clinical application, mass spectrometry (MS)-based steroid assay represents a promising tool in endocrine research. Recent studies indicate that monitoring the blood levels of individual sterols provides improved diagnostic insight into hyperlipidemia compared with immunoassays routinely used in clinical practice. Hypercortisolism and hyperaldosteronism can also be easily evaluated along with successful subtyping of adrenal diseases using MS-based methods, while metabolic signatures of sex steroids provide experimental evidence of abnormal puberty and male infertility. Many MS-based biological and clinical studies are based on liquid chromatography-mass spectrometry (LC-MS) coupled to electrospray ionization and tandem MS scan modes. However, gas chromatography-mass spectrometry (GC-MS) provides better chromatographic separation. Improved chromatographic resolution enables largescale steroid profiling to allow a bird-eye view and increase the chances of identifying potent biomarkers in endocrine research. In addition to the technical advantages of MS-based assays over immunoassays, minimizing the sample amounts with acceptable analytical sensitivity and standardization of surrogate materials provides cutting-edge tools for precision and personalized medicine.
URI
http://pubs.kist.re.kr/handle/201004/72996
ISSN
0040-8727
Appears in Collections:
KIST Publication > ETC
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