Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling

Title
Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling
Authors
김유찬전호정한형섭이경우서현선한상인송강일성두환김선홍박태성구자훈신미경박형원박옥규오숭주김대형현택환손동희
Issue Date
2021-03
Publisher
Advanced materials
Citation
VOL 온라인게재, 2007346
Abstract
Soft neuroprosthetics that monitor signals from sensory neurons and deliver motor information can potentially replace damaged nerves. However, achieving long­term stability of devices interfacing peripheral nerves is challenging, since dynamic mechanical deformations in peripheral nerves cause material degradation in devices. Here, a durable and fatigue­resistant soft neuroprosthetic device is reported for bidirectional signaling on peripheral nerves. The neuroprosthetic device is made of a nanocomposite of gold nanoshell (AuNS)­coated silver (Ag) flakes dispersed in a tough, stretchable, and self­healing polymer (SHP). The dynamic self­healing property of the nanocomposite allows the percolation network of AuNS­coated flakes to rebuild after degradation. Therefore, its degraded electrical and mechanical performance by repetitive, irregular, and intense deformations at the device?nerve interface can be spontaneously self­recovered. When the device is implanted on a rat sciatic nerve, stable bidirectional signaling is obtained for over 5 weeks. Neural signals collected from a live walking rat using these neuroprosthetics are analyzed by a deep neural network to predict the joint position precisely. This result demonstrates that durable soft neuroprosthetics can facilitate collection and analysis of large­sized in vivo data for solving challenges in neurological disorders.
URI
http://pubs.kist.re.kr/handle/201004/73010
ISSN
0935-9648
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE