Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling
- Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling
- 김유찬; 전호정; 한형섭; 이경우; 서현선; 한상인; 송강일; 성두환; 김선홍; 박태성; 구자훈; 신미경; 박형원; 박옥규; 오숭주; 김대형; 현택환; 손동희
- Issue Date
- Advanced materials
- VOL 온라인게재, 2007346
- Soft neuroprosthetics that monitor signals from sensory neurons and deliver motor information can potentially replace damaged nerves. However, achieving longterm stability of devices interfacing peripheral nerves is challenging, since dynamic mechanical deformations in peripheral nerves cause material degradation in devices. Here, a durable and fatigueresistant soft neuroprosthetic device is reported for bidirectional signaling on peripheral nerves. The neuroprosthetic device is made of a nanocomposite of gold nanoshell (AuNS)coated silver (Ag) flakes dispersed in a tough, stretchable, and selfhealing polymer (SHP). The dynamic selfhealing property of the nanocomposite allows the percolation network of AuNScoated flakes to rebuild after degradation. Therefore, its degraded electrical and mechanical performance by repetitive, irregular, and intense deformations at the device？nerve interface can be spontaneously selfrecovered. When the device is implanted on a rat sciatic nerve, stable bidirectional signaling is obtained for over 5 weeks. Neural signals collected from a live walking rat using these neuroprosthetics are analyzed by a deep neural network to predict the joint position precisely. This result demonstrates that durable soft neuroprosthetics can facilitate collection and analysis of largesized in vivo data for solving challenges in neurological disorders.
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