Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

Title
Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning
Authors
김유찬옥명렬전호정한형섭이재홍엄승훈송인석이상훈
Keywords
nanosecond laser; laser engraving; hydroxyapatite patterning; cell migration control; cell tracking
Issue Date
2021-10
Publisher
Bioactive Materials
Citation
VOL 6, NO 10-3619
Abstract
Hydroxyapatite, an essential mineral in human bones composed mainly of calcium and phosphorus, is widely used to coat bone graft and implant surfaces for enhanced biocompatibility and bone formation. For a strong implant?bone bond, the bone-forming cells must not only adhere to the implant surface but also move to the surface requiring bone formation. However, strong adhesion tends to inhibit cell migration on the surface of hydroxyapatite. Herein, a cell migration highway pattern that can promote cell migration was prepared using a nanosecond laser on hydroxyapatite coating. The developed surface promoted bone-forming cell movement compared with the unpatterned hydroxyapatite surface, and the cell adhesion and movement speed could be controlled by adjusting the pattern width. Live-cell microscopy, cell tracking, and serum protein analysis revealed the fundamental principle of this phenomenon. These findings are applicable to hydroxyapatite-coated biomaterials and can be implemented easily by laser patterning without complicated processes. The cell migration highway can promote and control cell movement while maintaining the existing advantages of hydroxyapatite coatings. Furthermore, it can be applied to the surface treatment of not only implant materials directly bonded to bone but also various implanted biomaterials implanted that require cell movement control.
URI
http://pubs.kist.re.kr/handle/201004/73011
ISSN
2452-199X
Appears in Collections:
KIST Publication > Article
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