A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement

Title
A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement
Authors
한서정Marchello A. CavittBrian M. Stoltz
Issue Date
2021-05
Publisher
Organic letters
Citation
VOL 23, NO 9-3303
Abstract
Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This operationally simple reaction is tolerant of many functional groups and applicable to the synthesis of various medium-sized ring nitrogen-containing heterocycles.
URI
http://pubs.kist.re.kr/handle/201004/73124
ISSN
1523-7060
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KIST Publication > Article
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