Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense

Title
Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense
Authors
권재영김민지김동철권하은류승목심상희YuanqiangGuo홍승범임정한김윤철오현철이동호
Issue Date
2021-08
Publisher
Bioorganic chemistry
Citation
VOL 113, 105012
Abstract
Inflammation is a vital process that maintains tissue homeostasis. However, it is widely known that uncontrolled inflammation can contribute to the development of various diseases. This study aimed to discover anti-inflammatory metabolites from Penicillium bialowiezense. Seven spiroditerpenoids, including two new compounds, breviones P and Q (1 and 2), were isolated and characterized by various spectroscopic and spectrometric methods. All isolated compounds were initially tested for their inhibitory effects against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages. Of these, brevione A (3) exhibited this activity with a half-maximal inhibitory concentration value of 9.5 μM. Further mechanistic studies demonstrated that 3 could suppress the expression of pro-inflammatory cytokines and mediators, such as NO, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12 by inhibiting the activation of nuclear factor-kappa B and c-Jun N-terminal kinase.
URI
http://pubs.kist.re.kr/handle/201004/73165
ISSN
0045-2068
Appears in Collections:
KIST Publication > Article
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