Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense
- Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense
- 권재영; 김민지; 김동철; 권하은; 류승목; 심상희; YuanqiangGuo; 홍승범; 임정한; 김윤철; 오현철; 이동호
- Issue Date
- Bioorganic chemistry
- VOL 113, 105012
- Inflammation is a vital process that maintains tissue homeostasis. However, it is widely known that uncontrolled inflammation can contribute to the development of various diseases. This study aimed to discover anti-inflammatory metabolites from Penicillium bialowiezense. Seven spiroditerpenoids, including two new compounds, breviones P and Q (1 and 2), were isolated and characterized by various spectroscopic and spectrometric methods. All isolated compounds were initially tested for their inhibitory effects against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages. Of these, brevione A (3) exhibited this activity with a half-maximal inhibitory concentration value of 9.5 μM. Further mechanistic studies demonstrated that 3 could suppress the expression of pro-inflammatory cytokines and mediators, such as NO, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12 by inhibiting the activation of nuclear factor-kappa B and c-Jun N-terminal kinase.
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