Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

Title
Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway
Authors
임혜원Md. Ataur RahmanMd. Abdul HannanRaju DashMD. Hasanur RahmanRokibul IslamMd Jamal UddinAbdullah Al Mamun SohagMd. Habibur Rahman
Issue Date
2021-05
Publisher
Frontiers in pharmacology
Citation
VOL 12, 639628
Abstract
Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of cancer development and regulation. Pharmacological targeting of autophagy and apoptosis signaling using phytochemicals therefore offers a promising strategy that is complementary to conventional cancer chemotherapy. In this review, we sought to highlight the molecular basis of the autophagic-apoptotic pathway to understand its implication in the pathobiology of cancer, and explore this fundamental cellular process as a druggable anticancer target. We also aimed to present recent advances and address the limitations faced in the therapeutic development of phytochemical-based anticancer drugs.
URI
http://pubs.kist.re.kr/handle/201004/73174
ISSN
1663-9812
Appears in Collections:
KIST Publication > Article
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