Preclinical study to improve microbubble­mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens

Title
Preclinical study to improve microbubble­mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
Authors
이병철임매순심신용전호윤Seunghyun LeeJinsik KimJung Hoon Kim
Keywords
Cancer Therapy; Microbubble-mediated drug delivery; Ultrasound; Interchangeable acoustic lens
Issue Date
2021-06
Publisher
Scientific Reports
Citation
VOL 11-10
Abstract
Focused ultrasound with microbubbles (FUS­MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUS­MBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUS­MB DDSs. We designed a lens suitable for an ultrasound­phased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. The DDS effects were evaluated in a rat hepatoma model using doxorubicin (DOX) treatment. A concave lens with a radius of curvature of 2.6 mm and a thickness of 4 mm was selected and fabricated. UUS­MBs with the acoustic lens at 60 Vpp for 32 cycles and a PRF of 1 kHz could induce MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS­ MBs in the acoustic lens treatment group had a higher concentration of DOX in the tumor than the control group. Our system suggests uses an acoustic lens to increase DDS effectiveness by providing sufficient ultrasound irradiation to the MBs.
URI
http://pubs.kist.re.kr/handle/201004/73261
ISSN
2045-2322
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE