Preclinical study to improve microbubblemediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
- Preclinical study to improve microbubblemediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
- 이병철; 임매순; 심신용; 전호윤; Seunghyun Lee; Jinsik Kim; Jung Hoon Kim
- Cancer Therapy; Microbubble-mediated drug delivery; Ultrasound; Interchangeable acoustic lens
- Issue Date
- Scientific Reports
- VOL 11-10
- Focused ultrasound with microbubbles (FUSMBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUSMBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUSMB DDSs. We designed a lens suitable for an ultrasoundphased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. The DDS effects were evaluated in a rat hepatoma model using doxorubicin (DOX) treatment. A concave lens with a radius of curvature of 2.6 mm and a thickness of 4 mm was selected and fabricated. UUSMBs with the acoustic lens at 60 Vpp for 32 cycles and a PRF of 1 kHz could induce MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS MBs in the acoustic lens treatment group had a higher concentration of DOX in the tumor than the control group. Our system suggests uses an acoustic lens to increase DDS effectiveness by providing sufficient ultrasound irradiation to the MBs.
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