Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer

Title
Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
Authors
이석이관희김재헌이택진김철기유용상송현석이동근유의상정우혁이수호한상국최명철안동준
Keywords
bioelectronic transducer; lipid membrane; Debye length; molecular detection
Issue Date
2021-06
Publisher
Nature Communications
Citation
VOL 12, 3741
Abstract
Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor?ligand bindings irrespective of ionic strength of bulky solutions by placing an ion-free water layer underneath the supported lipid bilayer. High-energy X-ray reflectometry together with the circuit analysis and molecular dynamics simulation discovered biochemical findings that effective electrical signals dominantly originated from the sub-nanoscale conformational change of lipids in the course of receptor?ligand bindings. Beyond thorough analysis on the underlying mechanism at the molecular level, the proposed supported lipid bilayer-field effect transistor platform ensures the world-record level of sensitivity in molecular detection with excellent reproducibility regardless of molecular charges and environmental ionic conditions.
URI
http://pubs.kist.re.kr/handle/201004/73382
ISSN
2041-1723
Appears in Collections:
KIST Publication > Article
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