The multi-functional roles of forkhead box protein O in skin aging and diseases
- The multi-functional roles of forkhead box protein O in skin aging and diseases
- 김민수; 문경미; 이민경; 황태역; 최춘환; 김형락; 이봉기
- FoxOs; melanogenesis; wound healing; acne; melanoma; Aging
- Issue Date
- Redox Biology
- VOL 46, 102101
- Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. The activation or deactivation of some FoxO family members is closely related to melanogenesis, wound healing, acne, and melanoma. In this review, we have discussed the recent findings that demonstrate the relationship between FoxOs and skin health as well as the underlying mechanisms associated with their functions.
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