Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Title
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
Authors
조일주신효근Sang Jeong KimEunee LeeSeungjoon LeeJae Jin ShinWoochul ChoiChanguk ChungSuho LeeJihye KimRyunhee KimTaesun YooIssac RhimJiSoo KimJoo Min ParkMin Whan JungSe-Bum PaikEunjoon KimSeungmin HaYe-Eun YooYoung Woo NohSoo Yeon LeeWoohyun KimTaekyung LeeKarl Deisseroth
Issue Date
2021-08
Publisher
Nature Communications
Citation
VOL 12, 5116
Abstract
NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv neuronal burst firing and social cognition. Shank2?/? mice, displaying improved sociability upon NMDAR activation, show impaired cortical social representation and inhibitory neuronal burst firing. Cortical Shank2?/? Pv neurons show decreased NMDAR activity, which suppresses the cooperation between NMDARs and gap junctions (GJs) for normal burst firing. Shank2?/? Pv neurons show compensatory increases in GJ activity that are not sufficient for social rescue. However, optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2?/? mice, similar to the NMDAR-dependent social rescue. Therefore, NMDARs and gap junctions cooperate to promote cortical Pv neuronal bursts and social cognition.
URI
http://pubs.kist.re.kr/handle/201004/74174
ISSN
2041-1723
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE