Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Joonki | - |
dc.contributor.author | Lee, Sang Heon | - |
dc.contributor.author | Zhang, Siqi | - |
dc.contributor.author | Bong SimKyu | - |
dc.contributor.author | Kim, Aaron Taehwan | - |
dc.contributor.author | Lee, Hara | - |
dc.contributor.author | Liu, Xiaoyong | - |
dc.contributor.author | Kim, Sang Moo | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.date.accessioned | 2024-01-12T06:32:55Z | - |
dc.date.available | 2024-01-12T06:32:55Z | - |
dc.date.created | 2023-11-06 | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1467-3037 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/79773 | - |
dc.description.abstract | Asthma is a chronic inflammatory disease involving structural changes to the respiratory system and severe immune responses mediated by allergic cytokines and pro-inflammatory mediators. Agarum cribrosum (AC) is a kind of seaweed which contains a phlorotannin, trifuhalol A. To evaluate its anti-allergic inflammatory effect against asthma, an ovalbumin inhalation-induced mouse asthma model was used. Histologic observations proved that trifuhalol A is minimizing the lung and tracheal structure changes as well as the infiltration of eosinophils and mast cells against ovalbumin inhalation challenge. From the serum and bronchoalveolar lavage fluid, ovalbumin-specific IgE and Th2-specific cytokines, IL-4, -5, and -13, were reduced with trifuhalol A treatment. In addition, IL-1β, IL-6, and TNF-α concentrations in lung homogenate were also significantly reduced via trifuhalol A treatment. Taken together, trifuhalol A, isolated from AC, was able to protect lung and airways from Th2-specific cytokine release, and IgE mediated allergic inflammation as well as the attenuation of IL-1β, IL-6, and TNF-α in lung, which results in the suppression of eosinophils and the mast cells involved asthmatic pathology. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Anti-Allergic Inflammatory Effect of Agarum cribrosum and Its Phlorotannin Component, Trifuhalol A, against the Ovalbumin-Induced Allergic Asthma Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/cimb45110557 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Current Issues in Molecular Biology, v.45, no.11, pp.8882 - 8893 | - |
dc.citation.title | Current Issues in Molecular Biology | - |
dc.citation.volume | 45 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 8882 | - |
dc.citation.endPage | 8893 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 001123317400001 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | INTERLEUKIN-4 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | AIRWAYS | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Agarum cribrosum | - |
dc.subject.keywordAuthor | trifuhalol A | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | allergic | - |
dc.subject.keywordAuthor | ovalbumin | - |
dc.subject.keywordAuthor | inflammation | - |
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