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dc.contributor.authorKim, Joonki-
dc.contributor.authorLee, Sang Heon-
dc.contributor.authorZhang, Siqi-
dc.contributor.authorBong SimKyu-
dc.contributor.authorKim, Aaron Taehwan-
dc.contributor.authorLee, Hara-
dc.contributor.authorLiu, Xiaoyong-
dc.contributor.authorKim, Sang Moo-
dc.contributor.authorKim, Su-Nam-
dc.date.accessioned2024-01-12T06:32:55Z-
dc.date.available2024-01-12T06:32:55Z-
dc.date.created2023-11-06-
dc.date.issued2023-11-
dc.identifier.issn1467-3037-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/79773-
dc.description.abstractAsthma is a chronic inflammatory disease involving structural changes to the respiratory system and severe immune responses mediated by allergic cytokines and pro-inflammatory mediators. Agarum cribrosum (AC) is a kind of seaweed which contains a phlorotannin, trifuhalol A. To evaluate its anti-allergic inflammatory effect against asthma, an ovalbumin inhalation-induced mouse asthma model was used. Histologic observations proved that trifuhalol A is minimizing the lung and tracheal structure changes as well as the infiltration of eosinophils and mast cells against ovalbumin inhalation challenge. From the serum and bronchoalveolar lavage fluid, ovalbumin-specific IgE and Th2-specific cytokines, IL-4, -5, and -13, were reduced with trifuhalol A treatment. In addition, IL-1β, IL-6, and TNF-α concentrations in lung homogenate were also significantly reduced via trifuhalol A treatment. Taken together, trifuhalol A, isolated from AC, was able to protect lung and airways from Th2-specific cytokine release, and IgE mediated allergic inflammation as well as the attenuation of IL-1β, IL-6, and TNF-α in lung, which results in the suppression of eosinophils and the mast cells involved asthmatic pathology.-
dc.languageEnglish-
dc.publisherMDPI-
dc.titleAnti-Allergic Inflammatory Effect of Agarum cribrosum and Its Phlorotannin Component, Trifuhalol A, against the Ovalbumin-Induced Allergic Asthma Model-
dc.typeArticle-
dc.identifier.doi10.3390/cimb45110557-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCurrent Issues in Molecular Biology, v.45, no.11, pp.8882 - 8893-
dc.citation.titleCurrent Issues in Molecular Biology-
dc.citation.volume45-
dc.citation.number11-
dc.citation.startPage8882-
dc.citation.endPage8893-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid001123317400001-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusCYTOKINES-
dc.subject.keywordPlusEOSINOPHILS-
dc.subject.keywordPlusINTERLEUKIN-4-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusAIRWAYS-
dc.subject.keywordPlusALPHA-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorAgarum cribrosum-
dc.subject.keywordAuthortrifuhalol A-
dc.subject.keywordAuthorasthma-
dc.subject.keywordAuthorallergic-
dc.subject.keywordAuthorovalbumin-
dc.subject.keywordAuthorinflammation-
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