Mild hyperthermia-induced apoptosis is dependent on p53 in human lymphoid cells
- Mild hyperthermia-induced apoptosis is dependent on p53 in human lymphoid cells
- 서영록; Martin L. Smith; 한성식; Daryl W. Fairbairn; Kim L. O'Neill; 류재천
- Issue Date
- Research Communications in Molecular Pathology and Pharmacology
- VOL 104, NO 3, 285-293
- Mild hyperthermia is known to enhance apoptosis. The p53 tumor-suppressor gene product has been shown to function in apoptosis in response to genotoxic stress. However, there is little information regarding the mechanism of p53-dependent apoptosis induced by heat stress. In present study, a p53 contribution in mild hyperthermia-induced apoptosis was investigated in human lymphoid system. After 30-minute exposure at 44 degrees C, the accumulation of p53 protein was clearly observed in TK6 and ML-1 cells. Using comet assay, the more significant sensitivity to hyperthermic apoptosis was found in TK6 (wild-type p53) than in WI-L2-NS (mutated in p53). Furthermore, the significantly rapid shifting from early apoptotic phase to late apoptotic was observed in heat-induced p53 TK6 cells. These findings suggest that p53-dependent apoptosis is efficaciously induced by mild hyperthermia as non-genotoxic stress in human lymphoid system.
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